High frequency of HBeAg-minus chronic HBsAg-positive liver disease in Egypt

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• 作者：El-Zayadi ; A. ; Sober ; M. ; Lavanchy ; D. ; Hasseeb ; N. ; Selim ; O. ; Mayerat ; C. ; Dabbous ; H.
• 关键词：Chronic hepatitis B ; HBV-DNA ; HBeAg ; Anti-HBe ; Egypt
• 刊名：International Hepatology Communications
• 出版年：1995
• 出版时间：April, 1995
• 年：1995
• 卷：3
• 期：4
• 页码：178-183
• 全文大小：294 K

文摘

The aim of this study was to establish if a correlation exists between the HBe antigen/anti-HBe-antibody profile (HBeAg/anti-HBe) and the hepatitis B virus DNA (HBV-DNA) among patients in Egypt with chronic liver disease induced by the hepatitis B virus. The results revealed that 44 out of 100 patients with chronic HBsAg-positive liver disease were also HBV-DNA-positive. Of these 44 cases, 5 (11.3 % ) were HBeAg-positive, 18 (41.0 % ) anti-HBe-positive and 21 (47.7 % ) negative for both markers. This finding showed that HBeAg-negative chronic hepatitis B represents more than 80 % of chronic hepatitis B cases in Egypt, suggesting that the HBeAg-minus variant of the hepatitis B virus characterizes the major infective agent.