Hippocampal changes in STZ-model of Alzheimer’s disease are dependent on sex
详细信息 查看全文
- 作者：Regina Biasibetti ; Joã ; o Paulo Almeida dos Santos ; Letí ; cia Rodrigues ; Krista Miné ; ia Wartchow ; Lucas Zingano Suardi ; Patrí ; cia Nardin ; Nicholas Guerini Selistre ; Dandara Vá ; zquez ; Carlos-Alberto Gonç ; alves ; casg@ufrgs.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer ; Astrocyte ; ChAT ; Glucose uptake ; Hippocampus ; Sex
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：205-214
- 全文大小：2522 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
Alzheimer’s disease (AD) has prevalence dependent on gender.
- class="label">•
We investigated alterations dependent on sex in a streptozotocin model of AD in rats.
- class="label">•
Hippocampal parameters were investigated 2, 4 and 8 weeks after streptozotocin.
- class="label">•
Cholinergic neurons and glucose uptake decrease were dependent on sex.
- class="label">•
S100B alteration in the hippocampus were also dependent on sex, but not GFAP.