Natural NO inhibitors from the leaves of Callicarpa kwangtungensis: Structures, activities, and interactions with iNOS

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• 作者：Shen Li^a ; Xiaocong Sun^a ; Yang Li^a ; Feng Liu^a ; Jun Ma^a ; Ling Tong^b ; Guochen Su^a ; Jing Xu^a ; ^{xujing611@nankai.edu.cn} ; Yasushi Ohizumi^c ; Dongho Lee^d ; Yuanqiang Guo^a ; ^{victgyq@nankai.edu.cn}
• 关键词：Callicarpa kwangtungensis ; 9 ; 10-seco-Abietane diterpenoid ; NO inhibitory activities ; iNOS ; Molecular docking ; Terpenoids
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：27
• 期：3
• 页码：670-674
• 全文大小：1280 K
• 卷排序：27

文摘

A phytochemical investigation to obtain new NO inhibitors resulted in the isolation of a new diterpenoid with a rare 9,10-seco-abietane skeleton (1) and twelve known terpenoids (2–13) from Callicarpa kwangtungensis. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses, and the absolute configuration of compound 1 was established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. The inhibitory activities on lipopolysaccharide-induced NO production in murine microglial BV-2 cells of these terpenoids were evaluated, and all of the compounds showed inhibitory effects. The following molecular docking studies showed interactions of the bioactive compounds with the iNOS protein.