Generation and immunogenicity of porcine circovirus type 2 chimeric virus-like particles displaying porcine reproductive and respiratory syndrome virus GP5 epitope B
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- 作者：Gaowei Hu1 ; hugaowei68@163.com" class="auth_mail" title="E-mail the corresponding author ; Naidong Wang1 ; naidongwang@hunau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wanting Yu ywt1017806202@163.com" class="auth_mail" title="E-mail the corresponding author ; Zhanfeng Wang 569608437@qq.com" class="auth_mail" title="E-mail the corresponding author ; Yawen Zou zy19911212@163.com" class="auth_mail" title="E-mail the corresponding author ; Yan Zhang myselfwo520@126.com" class="auth_mail" title="E-mail the corresponding author ; Aibing Wang bingaiwang@hunau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhibang Deng zbangd@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Yi Yang ; yiyang@hunau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Porcine circovirus type 2 ; Chimeric virus-like particles ; Porcine reproductive and respiratory syndrome virus GP5 epitope B ; Immune responses
- 刊名：Vaccine
- 出版年：2016
- 出版时间：7 April 2016
- 年：2016
- 卷：34
- 期：16
- 页码：1896-1903
- 全文大小：1246 K
文摘
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The homology modeling suggested the position between G85 and S86 of the PCV2 Cap is an ideal insertion site for GP5 epitope B.
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The PCV2 chimeric VLPs from recombinant Cap was successfully generated.
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The PCV2 chimeric VLPs retain the capacity of entry into PK-15 cells.
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The PCV2 chimeric VLPs are capable of inducing strong humoral and cellular immune responses in mice.
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The PCV2 chimeric VLPs provide a new platform to develop a bivalent or multivalent vaccine.