Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis

详细信息    查看全文

• 作者：Yanke Chen ; Hongxin Zhang ; Xingchun Gou ; Yohei Horikawa ; Jinliang Xing ; Zhinan Chen
• 关键词：Angiogenesis ; HAb18G/CD147 ; Human umbilical vein endothelial cells
• 刊名：Cancer Letters
• 出版年：2009
• 出版时间：8 June 2009
• 年：2009
• 卷：278
• 期：1
• 页码：113-121
• 全文大小：1380 K

文摘

Previous studies demonstrated that CD147 molecule, highly expressed on the surface of various malignant tumor cells, significantly correlated with the malignancy of these cancers; however, the role of HAb18G/CD147 in endothelial cells has yet to be established. In this study, we found that the expression of HAb18G/CD147 was significantly upregulated in activated HUVECs. The inhibition of HAb18G/CD147 expression by specific siRNA led to significantly decreased angiogenesis in vitro. Our data indicate that HAb18G/CD147 may regulate angiogenesis via several mechanisms including proliferation, survival, migration, MMPs secretion, and PI3K/Akt activation. Our findings for the first time suggest that upregulation of HAb18G/CD147 in activated HUVECs might play an important role in angiogenesis.