Effect of titanium dioxide nanoparticles on the cardiovascular system after oral administration
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- 作者：Zhangjian Chena ; czjczj01@163.com" class="auth_mail" title="E-mail the corresponding author ; Yun Wanga ; wangyun@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Lin Zhuoa ; jolin9017@sohu.com" class="auth_mail" title="E-mail the corresponding author ; Shi Chena ; chanvip@163.com" class="auth_mail" title="E-mail the corresponding author ; Lin Zhaoa ; sdjnzhaolin@163.com" class="auth_mail" title="E-mail the corresponding author ; Xianguo Luana ; luanxianguo3105@126.com" class="auth_mail" title="E-mail the corresponding author ; Haifang Wangb ; hwang@shu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Guang Jiaa ; jiaguangjia@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Titanium dioxide nanoparticles ; Cardiovascular effect ; Oral administration ; Cardiac damage ; Inflammatory response
- 刊名：Toxicology Letters
- 出版年：2015
- 出版时间：3 December 2015
- 年：2015
- 卷：239
- 期：2
- 页码：123-130
- 全文大小：1708 K
文摘
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This is the first research systematically evaluating the cardiovascular effects of oral intake of TiO2 NPs at doses simulating potential human exposure.
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Our research found that long-term ingestion of TiO2 NPs could lead to a slight cardiovascular risk.
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Cardiac damage and inflammatory response caused by TiO2 NPs were suggested as the possible reasons for cardiovascular adverse effects.