- 作者：William Nseir ; Julnar Mograbi ; Zuhair Abu-Rahmeh ; Mahmud Mahamid ; Omar Abu-Elheja ; Adel Shalata
- 关键词：Recurrent tonsillopharyngitis ; Group A Streptococcus ; Vitamin D ; Adults
- 刊名：International Journal of Infectious Diseases
- 出版年：2012
- 出版时间：October, 2012
- 年：2012
- 卷：16
- 期：10
- 页码：e735-e738
- 全文大小：192 K
Summary
Objectives
To determine the association between recurrent group A streptococcal (GAS) tonsillopharyngitis and serum 25-hydroxy (25(OH)) vitamin D among adult subjects.Methods
Adult patients with tonsillopharyngitis between January 2007 and December 2009 were reviewed and identified retrospectively. Cases with a medical history of recurrent GAS tonsillopharyngitis were compared to age- and gender-matched individuals without a medical history of GAS tonsillopharyngitis. Recurrent tonsillopharyngitis was defined as three or more episodes of GAS tonsillopharyngitis per year for a period of two consecutive years.
Results
Fifty-four cases with recurrent GAS tonsillopharyngitis and 50 controls were enrolled. There were no significant differences between cases and controls with regard to mean age (41 ¡À 13 vs. 42 ¡À 12 years; p = 0.7) and male gender (55 % vs. 54 % ; p = 0.6). Mean serum levels of 25(OH) vitamin D among subjects with recurrent GAS tonsillopharyngitis were significantly lower from the controls (11.5 ng/ml ¡À 4.7 vs. 26 ng/ml ¡À 7; p = 0.001). Multiple regression analysis showed that a serum 25(OH) vitamin D level <20 ng/ml was associated with recurrent GAS tonsillopharyngitis (odds ratio 1.62, 95 % confidence interval 1.51-1.76; p < 0.001).
Conclusions
Our findings indicate a link between vitamin D deficiency and the recurrence of GAS tonsillopharyngitis.