Discovery of potential colorectal cancer serum biomarkers through quantitative proteomics on the colonic tissue interstitial fluids from the AOM-DSS mouse model
详细信息 查看全文
- 作者：Yang Wanga ; b ; Qiang Shana ; Guixue Houa ; b ; Ju Zhanga ; Jian Baia ; Xiaolei Lvc ; Yingying Xiea ; b ; Huishan Zhuc ; Siyuan Sua ; b ; Yang Lic ; Jin Zid ; Liang Lind ; Wenxiao Hane ; Xinhua Zhaoe ; Hongying Wange ; Ningzhi Xuf ; Lin Wua ; wul@big.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Xiaomin Loua ; louxm@big.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Siqi Liua ; d ; siqiliu@genomics.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Colorectal cancer ; AOM&ndash ; DSS mouse model ; Tissue interstitial fluid ; Serum biomarker ; iTRAQ ; MRM
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：30 January 2016
- 年：2016
- 卷：132
- 期：Complete
- 页码：31-40
- 全文大小：1533 K
文摘
- •
Dynamic TIF proteomics found 62 consecutively changed proteins related to CRC growth.
- •
Targeted proteomics verified LRG1 and TUBB5 as potential CRC serum biomarkers.
- •
Our study provides a promising pipeline to discover & verify tumor serum biomarkers.