The ABCG2 efflux transporter from rabbit placenta: Cloning and functional characterization
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- 作者：Sandra Halwachsa ; halwachs@vetmed.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author ; Carsten Kneuerb ; Carsten.Kneuer@bfr.bund.de" class="auth_mail" title="E-mail the corresponding author ; Katrin Gohlschb ; 1 ; gohlsch.katrin@gmx.de" class="auth_mail" title="E-mail the corresponding author ; Marian Mü ; llera ; loki.mm21@web.de" class="auth_mail" title="E-mail the corresponding author ; Vera Ritzb ; Vera.Ritz@bfr.bund.de" class="auth_mail" title="E-mail the corresponding author ; Walther Honschaa ; honscha@vetmed.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABCG2/BCRP efflux transporter ; Placenta barrier ; Rabbit ; developmental toxicity testing ; Active drug transport ; MDCKII in vitro model
- 刊名：Placenta
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：8-15
- 全文大小：995 K
文摘
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Cloning of the ABCG2 efflux transporter from rabbit placenta (rbABCG2).
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Identification of the structural homology of rbABCG2 and hABCG2.
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Detection of the functional activity of the ABCG2 transporter in rabbit placenta.
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The rbABCG2 and the hABCG2 have comparable drug substrate specificity.
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MDCKII-rbABCG2 cells are a suitable model to study transport in rabbit placenta.