Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors

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• 作者：Lucie Vandromme ; Sandrine Piguel ; Olivier Lozach ; Laurent Meijer ; Michel Legraverend and David S. Grierson
• 关键词：Purine ; Cdk ; Inhibitors ; Suzuki cross-coupling
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 出版时间：15 June 2006
• 年：2006
• 卷：16
• 期：12
• 页码：3144-3146
• 全文大小：118 K

文摘

A new series of 2-aryl-substituted purine derivatives has been synthesized by Suzuki Pd(0) coupling reactions. Moderate in vitro inhibitory activity against Cdk1 and Cdk5 was observed. These compounds are inactive against GSK3.