Utility of Contrast-enhanced Ultrasonography with Perflubutane for Determining Histologic Grade in Hepatocellular Carcinoma

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• 作者：Toshifumi Tada^&lowast ; ; ^{tadat0627@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Takashi Kumada^&lowast ; ; Hidenori Toyoda^&lowast ; ; Takanori Ito^&lowast ; ; Yasuhiro Sone^&dagger ; ; Yuji Kaneoka^&Dagger ; ; Atsuyuki Maeda^&Dagger ; ; Seiji Okuda^§ ; ; Katsuhiko Otobe^¶ ; ; Kenichi Takahashi^¶ ;
• 关键词：Hepatocellular carcinoma ; Histologic grade ; Contrast-enhanced ultrasonography
• 刊名：Ultrasound in Medicine & Biology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：41
• 期：12
• 页码：3070-3078
• 全文大小：893 K

文摘

The purpose of this study was to clarify the diagnostic value of contrast-enhanced ultrasonography (CEUS) with perflubutane in determining the histologic grade in hepatocellular carcinoma (HCC). A total of 147 surgically resected HCCs were dichotomized as well differentiated HCC (wd-HCC) and moderately- or poorly-differentiated HCC (mp-HCC). CEUS findings were evaluated during the arterial phase (vascularity, level and shape of enhancement), portal phase (presence or absence of washout) and post-vascular phase (echo intensity and shape). Receiver operating characteristic (ROC) curve analysis for the diagnosis of mp-HCC yielded area under the ROC curve (A_z) values for arterial phase vascularity and portal phase washout of 0.910 and 0.807, respectively. The A_z value for the combination of vascularity and washout for the diagnosis of mp-HCC was 0.956 (95% confidence interval, 0.910–0.979), corresponding to high diagnostic value. In conclusion, CEUS can provide high-quality imaging assessment for determining the histologic grade of HCCs.