Genetic and environmental factors on the relation of lung function and arterial stiffness

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• 作者：David Laszlo Tarnoki^a ; ^m ; ^{tarnoki4@gmail.com} ; Adam Domonkos Tarnoki^a ; ^m ; ^{tarnoki2@gmail.com} ; Zsofia Lazar^b ; ^{zsofia.lazar@yahoo.com} ; Emanuela Medda^c ; ^{emanuela.medda@iss.it} ; Levente Littvay^d ; ^{levi@littvay.com} ; Rodolfo Cotichini^c ; ^{rodolfo.cotichini@iss.it} ; Corrado Fagnani^c ; ^{corrado.fagnani@iss.it} ; Maria Antonietta Stazi^c ; ^{antonia.stazi@iss.it} ; Lorenza Nisticó ; ^c ; ^{lorenza.nistico@iss.it} ; Pierleone Lucatelli^e ; ^{pierleone.lucatelli@gmail.com} ; Emanuele Boatta^e ; ^{emanuele.boatta@yahoo.it} ; Chiara Zini^e ; ^{zini.chiara@gmail.com} ; Fabrizio Fanelli^e ; ^{fabrizio.fanelli@uniroma1.it} ; Claudio Baracchini^f ; ^{claudiobaracchini@tin.it} ; Giorgio Meneghetti^f ; ^{giorgio.meneghetti@unipd.it} ; Gyorgy Jermendy^g ; ^{gyjermendy@mail.datanet.hu} ; Istvá ; n Pré ; da^h ; ⁱ ; ^{predadr@gmail.com} ; Ró ; bert Gá ; bor Kiss^h ; ⁱ ; ^{robertgaborkiss@gmail.com} ; Kinga Karlinger^a ; ^{kinga.karlking@gmail.com} ; Agnes Lannert^j ; ^{zanzarita@freemail.hu} ; Giuseppe Schillaci^k ; ^{skill@unipg.it} ; Andrea Agnes Molnar^h ; ⁱ ; ^{molnandi@gmail.com} ; Zsolt Garami^l ; ^{ZGarami@tmhs.org} ; Viktor Berczi^a ; ^{berczi@hotmail.com} ; Ildiko Horvath^b ; ^{kiss.horvath@t-online.hu}
• 关键词：Pulmonary function test ; Forced vital capacity ; Augmentation index ; Pulse wave velocity ; Genetics
• 刊名：Respiratory Medicine
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：107
• 期：6
• 页码：927-935
• 全文大小：243 K

文摘

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lass=""h3"">Summary

lass=""h4"">Background

An association between reduced lung function and increased cardiovascular risk has been reported, but the underlying mechanisms are unknown. The aim of this study was to assess the heritability of lung function and to estimate its genetic association with arterial stiffness.

lass=""h4"">Methods

150 monozygotic and 42 dizygotic healthy Hungarian and American Caucasian twin pairs (age 43?¡À?17 years) underwent spirometry (forced vital capacity/FVC/, forced expiratory volume in 1?s/FEV₁/; MIR Minispir, USA); and their brachial and central augmentation indices (AIx), and aortic pulse wave velocity (PWV) were measured by oscillometric Arteriograph (TensioMed Ltd, Budapest, Hungary). Phenotypic correlations and bivariate Cholesky decomposition models were applied.

lass=""h4"">Results

Age-, sex-, country- and smoking-adjusted heritability of FEV₁, percent predicted FEV₁, FVC and percent predicted FVC were 73 % (95 % confidence interval /CI/: 45-85 % ), 28 % (95 % CI: 0-67 % ), 68 % (95 % CI: 20-81 % ) and 45 % (95 % CI: 0-66 % ), respectively. Measured and percent predicted FVC and FEV₁ values showed no significant phenotypic correlations with AIx or aortic PWV, except for phenotypic twin correlations between measured FEV₁, FVC with brachial or aortic augmentation indices which ranged between ?0.12 and ?0.17. No genetic covariance between lung function and arterial stiffness was found.

lass=""h4"">Conclusions

Lung function is heritable and the measured FVC and FEV are phenotypically, but not genetically, associated with augmentation index, a measure of wave reflection. This relationship may in turn reveal further associations leading to a better mechanistic understanding of vascular changes in various airway diseases.