Echo Decorrelation Imaging of Rabbit Liver and VX2 Tumor during In Vivo Ultrasound Ablation
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- 作者：Tyler R. Fosnight&lowast ; ; Fong Ming Hooi&lowast ; ; Ryan D. Keil&lowast ; ; Alexander P. Ross&lowast ; ; Swetha Subramanian&lowast ; ; Teckla G. Akinyi&lowast ; ; Jakob K. Killin&lowast ; ; Peter G. Barthe&dagger ; ; Steven M. Rudich&Dagger ; ; Syed A. Ahmad§ ; ; Marepalli B. Rao&lowast ; ; ‖ ; T. Douglas Mast&lowast ; ; doug.mast@uc.edu
- 关键词：Echo decorrelation imaging ; Therapy monitoring ; Thermal ablation ; Bulk ultrasound ablation ; High-intensity focused ultrasound
- 刊名：Ultrasound in Medicine & Biology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：43
- 期：1
- 页码：176-186
- 全文大小：1658 K
- 卷排序：43
文摘
In open surgical procedures, image-ablate ultrasound arrays performed thermal ablation and imaging on rabbit liver lobes with implanted VX2 tumor. Treatments included unfocused (bulk ultrasound ablation, N = 10) and focused (high-intensity focused ultrasound ablation, N = 13) exposure conditions. Echo decorrelation and integrated backscatter images were formed from pulse-echo data recorded during rest periods after each therapy pulse. Echo decorrelation images were corrected for artifacts using decorrelation measured prior to ablation. Ablation prediction performance was assessed using receiver operating characteristic curves. Results revealed significantly increased echo decorrelation and integrated backscatter in both ablated liver and ablated tumor relative to unablated tissue, with larger differences observed in liver than in tumor. For receiver operating characteristic curves computed from all ablation exposures, both echo decorrelation and integrated backscatter predicted liver and tumor ablation with statistically significant success, and echo decorrelation was significantly better as a predictor of liver ablation. These results indicate echo decorrelation imaging is a successful predictor of local thermal ablation in both normal liver and tumor tissue, with potential for real-time therapy monitoring.