Melanoma antigen-A11 regulates substrate-specificity of Skp2-mediated protein degradation

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• 作者：Shifeng Su^a ; ¹ ; Xiaoyu Chen^a ; ² ; Jiang Geng^a ; ³ ; John T. Minges^a ; ⁴ ; Gail Grossman^a ; Elizabeth M. Wilson^a ; ^b ; ^{emw@med.unc.edu}
• 关键词：Androgen receptor ; Melanoma antigen-A11 ; MAGE-A11 ; Skp2 ; Cyclin A ; E2F1
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：1-9
• 全文大小：1245 K
• 卷排序：439

文摘

Androgen receptor signaling involves melanoma antigen-A11 (MAGE-A11) coregulator. MAGE-A11 interacts with Skp2 (S phase kinase-associated protein) and cyclin A. MAGE-A11 and Skp2 interact competitively with cyclin A. E2F1 transcription factor is stabilized in an E2F1-MAGE-A11-Skp2 complex. MAGE-A11 regulates the substrate-specificity of Skp2-mediated protein degradation.