Simultaneous quantification and semi-quantification of ginkgolic acids and their metabolites in rat plasma by UHPLC-LTQ-Orbitrap-MS and its application to pharmacokinetics study
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- 作者：Yiyun Qian<sup>asup> ; Zhenhua Zhu<sup>asup> ; Jin-ao Duan<sup>asup><sup> ; sup><sup>dja@njutcm.edu.cnsup> ; Sheng Guo<sup>asup> ; Erxin Shang<sup>asup> ; Jinhua Tao<sup>asup><sup> ; sup><sup>bsup> ; Shulan Su<sup>asup> ; Jianming Guo<sup>asup>
- 关键词：Ginkgolic acids ; Pharmacokinetics ; UHPLC&ndash ; LTQ&ndash ; Orbitrap&ndash ; MS ; Metabolites
- 刊名：Journal of Chromatography B
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：1041-1042
- 期：Complete
- 页码：85-93
- 全文大小：2278 K
- 卷排序：1041
文摘
Pharmacokinetics study on ginkgolic acids in rat plasma after oral administration of 3 dosage groups. Metabolites of GA (15:1) and GA (17:1) in plasma were identified. Obtained the curves of relative changes of six metabolites during the metabolic process.