Effects of zinc and iron supplementation fail to improve motor and language milestone scores of infants and toddlers

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• 作者：Pamela J. Surkan ; Sc.D.^a ; ^{psurkan@jhsph.edu} ; Emily H. Siegel ; Ph.D.^a ; Shivani A. Patel ; M.P.H.^b ; Joanne Katz ; Sc.D.^a ; Subarna K. Khatry ; M.B.B.S.^a ; ^c ; Rebecca J. Stoltzfus ; Ph.D.^d ; Steven C. LeClerq ; M.P.H.^a ; ^c ; James M. Tielsch ; Ph.D.^a
• 关键词：Micronutrients ; Iron ; Zinc ; Psychomotor performance ; Language development ; Children ; Nepal
• 刊名：Nutrition
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：29
• 期：3
• 页码：542-548
• 全文大小：484 K

文摘

Objective

To assess the effects of zinc and iron-folic acid supplementation on motor and language milestones in Nepali children.

Methods

Five hundred forty-four children 4 to 17 mo old residing in Ishwarpur, Nepal were randomized to receive placebo, iron-folic acid, zinc, or zinc plus iron-folic acid daily. Data were collected at baseline and at 3-mo intervals for 1 y. The main effects of zinc and iron folic-acid supplementation were estimated for motor and language milestones. Crude and adjusted mean cumulative changes in scores from visits 1 to 5 and adjusted rates of change were modeled.

Results

Adjusted differences in motor milestone scores from visits 1 to 5 and rates of change were not significantly different for the zinc and non-zinc groups (adjusted ¦Â?=??0.7, 95 % confidence interval [CI] ?1.4 to 0.01; adjusted ¦Â?=??0.1, 95 % CI ?0.5 to 0.3, respectively). Motor milestones in children receiving and not receiving iron supplements were not significantly different (adjusted ¦Â?=?0.1, 95 % CI ?0.7 to 0.8, from visits 1 to 5; adjusted ¦Â?=?0.1, 95 % CI ?0.3 to 0.5, for rate of change). Children receiving zinc had a 0.8 lower mean crude change in language score from visits 1?to 5 compared with children not receiving zinc (95 % CI ?1.3 to ?0.3), but the significance was lost after adjustment (adjusted ¦Â?=??0.2, 95 % CI ?0.6 to 0.2, for visits 1 to 5; ¦Â?=??0.1, 95 % CI ?0.3 to 0.2, for rate of change). No significant difference in motor or language milestone scores from iron supplementation was observed.

Conclusion

After 1 y, neither zinc nor iron-folic acid supplementation in Nepali children improved the attainment of motor or language milestones.