Effect of Hippophae rhamnoides

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• 作者：Monika Jain ; L. Ganju ; A. Katiyal ; Y. Padwad ; K.P. Mishra ; S. Ch ; a ; D. Karan ; K.M.S. Yogendra ; R.C. Sawhney
• 关键词：Seabuckthorn leaf extract ; Dengue virus ; Macrophages ; Plaque number
• 刊名：Phytomedicine
• 出版年：2008
• 出版时间：17 October 2008
• 年：2008
• 卷：15
• 期：10
• 页码：793-799
• 全文大小：268 K

文摘

Dengue virus occurs as four distinct serotypes, called Dengue 1, 2, 3, and 4. Symptomatic dengue virus infection ranges from a self limited febrile illness, dengue fever (DF), to a more severe disease, dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). The anti-Dengue treatment is severely hampered as no specific therapeutic agents are available. Even present treatment strategies for Dengue are more supportive than curative. In the present study anti-dengue activity of Hippophae rhamnoides (Seabuckthorn, SBT) leaf extract was evaluated in Dengue virus type-2 infected blood-derived human macrophages as macrophages are the primary target of Dengue virus infection. Infected cells were treated with SBT leaf extract and compared with commercially available anti-viral drug, Ribavirin. The extract was able to maintain the cell viability of Dengue-infected cells at par with Ribavirin along with the decrease and increase in TNF-α and IFN-γ respectively. Anti-dengue activity of SBT extract was further determined by the traditional plaque assay. These observations suggest that the SBT leaf extract has a significant anti-dengue activity and has the potential for the treatment of Dengue.