Gut microbiota composition and relapse risk in pediatric MS: A pilot study
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- 作者：Helen Tremletta ; helen.tremlett@ubc.ca" class="auth_mail" title="E-mail the corresponding author ; Douglas W. Fadroshb ; Ali A. Faruqib ; Janace Hartb ; Shelly Roalstadc ; Jennifer Gravesb ; Susan Lynchb ; Emmanuelle Waubantb ; on behalf of the US Network of Pediatric MS CentersGreg Aaen1 ; Anita Belman2 ; Leslie Benson3 ; Charlie Casper4 ; Tanuja Chitnis3 ; Mark Gorman3 ; Yolanda Harris7 ; Lauren Krupp2 ; Tim E. Lotze6 ; Sabina Lulu7 ; Jayne Ness5 ; Cody Olsen4 ; Erik Roan4 ; Moses Rodriguez5 ; John Rose4 ; Timothy C. Simmons4 ; Jan-Mendelt Tillema5 ; Wendy Weber4 ; Bianca Weinstock-Guttman8
- 关键词：Pediatric multiple sclerosis ; Gut microbiota ; 16S rRNA ; Relapse risk ; Survival analyses ; Kaplan-Meier ; Cox regression
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：363
- 期：Complete
- 页码：153-157
- 全文大小：807 K
文摘
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Gut microbiota was associated with subsequent relapse risk in pediatric multiple sclerosis.
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Fusobacteria depletion increased relapse risk (hazard ratio = 3.2; 95% CI: 1.2–9.0).
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Findings could offer new targets to alter the MS disease course.