CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia
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- 作者：Jeevisha Bajaj1 ; 2 ; 3 ; 4 ; 11 ; Takaaki Konuma1 ; 2 ; 3 ; 4 ; 11 ; Nikki K. Lytle1 ; 2 ; 3 ; 4 ; Hyog Young Kwon1 ; 2 ; 3 ; 4 ; Jailal N. Ablack4 ; Joseph M. Cantor4 ; David Rizzieri5 ; Charles Chuah6 ; Vivian G. Oehler7 ; Elizabeth H. Broome3 ; 8 ; Edward D. Ball3 ; 9 ; Edward H. van der Horst10 ; Mark H. Ginsberg3 ; 4 ; mhginsberg@ucsd.edu" class="auth_mail" title="E-mail the corresponding author ; Tannishtha Reya1 ; 2 ; 3 ; 4 ; 12 ; treya@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：CD98 ; leukemia ; cancer ; cancer stem cell ; microenvironment ; imaging ; integrin ; adhesion ; acute myelogenous leukemia ; SLC3A2
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：14 November 2016
- 年：2016
- 卷：30
- 期：5
- 页码：792-805
- 全文大小：4027 K
文摘
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Development and analysis of conditional CD98−/− model in the hematopoietic system
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CD98 loss impairs propagation of established AML in mouse models of disease
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Antibody-mediated CD98 blockade impairs primary human AML growth
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CD98-mediated adhesion to vasculature promotes leukemia stem cell maintenance