Association of the DRD2 CA_n-STR and DRD3 Ser9Gly polymorphisms with Parkinson's disease and response to dopamine agonists

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• 作者：Shaoqing Xu ; Jiujiang Liu ; Xiaodong Yang ; Yiwei Qian ; Qin Xiao ; ^{xiaoqin67@medmail.com.cn}
• 关键词：DRD2 CAn-STR ; DRD3 Ser9Gly ; Parkinson's disease ; Dopamine agonists
• 刊名：Journal of the Neurological Sciences
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：372
• 期：Complete
• 页码：433-438
• 全文大小：222 K
• 卷排序：372

文摘

We investigated the association between DRD2 CAn-STR as well as DRD3 Ser9Gly polymorphisms and doses of DAs, especially pramipexole We found that PD patients carrying DRD3 Ser9Gly Gly/Gly genotype took more pramipexole than patients with Ser/Ser and Ser/Gly genotypes Our study indicated that to obtain better therapeutic results, higher doses of pramipexole should be used in patients with Gly/Gly genotype Our results provide some insights into the pharmacogenomics of PD treatment and may help to better understand individual variability in response to DAs