Synthetic, enzyme kinetic, and protein crystallographic studies of C-β-d-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase
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- 作者：Anastassia L. Kantsadia ; 1 ; É ; va Bokorb ; 1 ; Sá ; ndor Kunb ; 1 ; George A. Stravodimosa ; Demetra S.M. Chatzileontiadoua ; Demetres D. Leonidasa ; ddleonidas@bio.uth.gr" class="auth_mail" title="E-mail the corresponding author ; É ; va Juhá ; sz-Tó ; thb ; Andrea Szaká ; csb ; Gyula Battab ; Tibor Docsac ; Pá ; l Gergelyc ; Lá ; szló ; Somsá ; kb ; somsak.laszlo@science.unideb.hu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diabetes type 2 ; Glycogen phosphorylase inhibitor ; C-Glucopyranosyl derivative ; Pyrrole ; Indole ; Imidazole
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：10 November 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：737-745
- 全文大小：2031 K
文摘
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Synthesis of C-β-d-glucopyranosyl pyrrole, indole, and imidazole derivatives.
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Nanomolar inhibition of human liver glycogen phosphorylase.
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X-Ray crystallography of glycogen phosphorylase‒C-glucosyl imidazole complexes.