The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity
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- 作者：Xiufang Cheng ; b ; Yue Wangc ; Tianquan Fengd ; Ming Yie ; f ; Xingan Zhangb ; zhangxinan@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Da Zhoua ; zhouda@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cancer stem cell model ; Multi-phenotypic model ; Transient dynamics ; Cell plasticity
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：7 February 2016
- 年：2016
- 卷：390
- 期：Complete
- 页码：40-49
- 全文大小：723 K
文摘
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We give a comparative study between the hierarchical and reversible cancer models.
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The reversible model performs better in capturing cell-state dynamics.
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The phenotypic plasticity facilitates the heterogeneity of cancer.