Cytotoxic and apoptotic effects of constituents from Millettia pachycarpa Benth

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• 作者：Haoyu Ye^a ; Afu Fu^b ; Wenshuang Wu^a ; Yanfang Li^c ; Guangcheng Wang^a ; Minghai Tang^a ; Shucai Li^a ; Shichao He^a ; Shijie Zhong^a ; Huijun Lai^a ; Jianhong Yang^a ; Minli Xiang^a ; Aihua Peng^a ; ^{peng_aihua@163.com} ; Lijuan Chen^a ; ^{lijuan17@hotmail.com}
• 关键词：Millettia pachycarpa Benth ; Separation ; Millepachine ; Cytotoxicity ; Apoptosis
• 刊名：Fitoterapia
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：83
• 期：8
• 页码：1402-1408
• 全文大小：674 K

文摘

The aim of this study is to investigate the cytotoxic and apoptotic effects of constituents from the seeds of Millettia pachycarpa Benth. Fourteen compounds (rong class=""boldFont"">1rong>-rong class=""boldFont"">14rong>) including one novel chalcone (rong class=""boldFont"">10rong>) were isolated as active principles from Chinese herbal medicine M. pachycarpa Benth. Their structures were identified by using spectroscopic methods. All isolates were then evaluated for their cytotoxic effects against several cancer cell lines (HepG2, C26, LL2 and B16) with cisplatin as a positive control. And their apoptosis-inducing effects were tested against HeLa-C3 cells with taxol as a positive control. Both studies showed that compounds rong class=""boldFont"">1rong>, rong class=""boldFont"">2rong>, rong class=""boldFont"">7rong> and rong class=""boldFont"">10rong> demonstrated significant cytotoxic and apoptotic effects against cancer cells. Moreover, in the apoptosis assay the novel chalcone (rong class=""boldFont"">10)rong> showed strong apoptosis inducing effects at a concentration of 2 ¦ÌM within 36 h. It was found to be the most potent apoptotic inducer of the compounds isolated from M. pachycarpa Benth.