We studied iguanas pre-Columbian remains found in Guadeloupe islands (25 deposits).
Only the endemic I. delicatissima occurred during pre-Columbian times (no I. iguana).
Past iguanas occurred on all islands and could be very large (body length >50 cm).
Selection of hunted iguanas by pre-Columbian people differs among islands.
I. delicatissima is now largely extinct and undergone a 20% size reduction.