Identification of transcription factors and gene clusters in rabbit smooth muscle cells during high flow-induced vascular remodeling via microarray
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- 作者：Zhaolong Zhanga ; 1 ; Pengfei Yanga ; 1 ; Pengfei Yaob ; 1 ; Dongwei Daia ; Ying Yua ; Yu Zhoua ; Qinghai Huanga ; ocinhqh@163.com" class="auth_mail" title="E-mail the corresponding author ; Jianmin Liua ; chstroke@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SMCs ; smooth muscle cells ; GO ; gene ontology ; TFs ; transcription factors ; ROS ; reactive oxygen species ; IHC ; immunohistochemistry ; IF ; immunofluorescence ; IGF1 ; insulin-like growth factor 1 ; PRKG1 ; cGMP-dependent protein kinase 1 ; PTH1R ; parathyroid hormone 1 receptor ; FOXN4 ; forkhead box N4 ; RYR-2 ; ryanodine receptor 2 ; GPX7 ; glutathione peroxidase 7 ; CACNB2 ; voltage-dependent l-type calcium channel subunit beta-2 ; PTHLH ; parathyroid hormone-like hormone ; ENPP1 ; ectonucleotide pyrophosphatase/p
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：407-414
- 全文大小：817 K
文摘
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ECM-related genes are enriched during high flow-induced vascular remodeling.
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Metabolic and immune function-related pathways result in vascular remodeling.
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SMCs exhibit 25 differentially expressed TFs in response to hemodynamic stress.
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FOXN4 regulates the promoter activity of MMP2 and MMP9.