Embryogenesis of triple neural tube defects: sonic hedgehog—a key?

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• 作者：Santosh Kumar Mahalik^a ; Dhananjay Vaze^a ; Toijam Soni Lyngdoh^a ; Manoj Kumar Tewari^b ; Kannan Laksmi Narasimhan^a ; ^{narasimhankl@gmail.com}
• 关键词：Multiple neural tube defects ; Neurulation ; Neural tube closure ; Sonic hedgehog
• 刊名：Journal of Pediatric Surgery
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：46
• 期：2
• 页码：e5-e8
• 全文大小：412 K

文摘

Neural tube closure is a complex spatio-temporal process. Multiple neural tube defects (NTDs) in a single patient are extremely rare. Only a few cases of multiple NTDs have been reported in the world literature, including less than 20 cases of double NTDs and 3 cases of triple NTDs. We report a fourth case of triple NTDs and review the literature regarding the embryogenesis. An effort is made to understand the theories of neural tube closure in light of recent advances in molecular biology and identification of the signaling pathways involved.