Zearalenone exposure impairs ovarian primordial follicle formation via down-regulation of Lhx8 expression in vitro

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• 作者：Guo-Liang Zhang^a ; Xiao-Feng Sun^b ; Yan-Zhong Feng^c ; Bo Li^d ; Ya-Peng Li^b ; Fan Yang^b ; Charles Martin Nyachoti^e ; Wei Shen^b ; Shi-Duo Sun^a ; ^{ssdsm@tom.com} ; Lan Li^b ; ^{lilan9600@126.com}
• 关键词：Folliculogenesis ; Primordial follicle formation ; Zearalenone ; Lhx8
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：317
• 期：Complete
• 页码：33-40
• 全文大小：1593 K
• 卷排序：317

文摘

First time to evaluate the impact of ZEA on primordial follicle formation ZEA exposure increases oocyte apoptosis and delays germ cell cyst breakdown. ZEA exposure impairs the expression of LHX8 by affecting its DNA methylation.