Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: Rat cerebral glioma blood volume determination

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• 作者：Xin Li ; William D. Rooney ; Csan&#xe1 ; d G. V&#xe1 ; rallyay ; Seymur Gahramanov ; Leslie L. Muldoon ; James A. Goodman ; Ian J. Tagge ; Audrey H. Selzer ; Martin M. Pike ; Edward A. Neuwelt ; Charles S. Springer
• 关键词：DCE-MRI ; Water exchange ; Shutter-speed ; Pharmacokinetics ; Patlak Plot
• 刊名：Journal of Magnetic Resonance
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：206
• 期：2
• 页码：190-199
• 全文大小：737 K

文摘

The accurate mapping of the tumor blood volume (TBV) fraction (v_b) is a highly desired imaging biometric goal. It is commonly thought that achieving this is difficult, if not impossible, when small molecule contrast reagents (CRs) are used for the T₁-weighted (Dynamic-Contrast-Enhanced) DCE-MRI technique. This is because angiogenic malignant tumor vessels allow facile CR extravasation. Here, a three-site equilibrium water exchange model is applied to DCE-MRI data from the cerebrally-implanted rat brain U87 glioma, a tumor exhibiting rapid CR extravasation. Analyses of segments of the (and the entire) DCE data time-course with this “shutter-speed” pharmacokinetic model, which admits finite water exchange kinetics, allow TBV estimation from the first-pass segment. Pairwise parameter determinances were tested with grid searches of 2D parametric error surfaces. Tumor blood volume (v_b), as well as v_e (the extracellular, extravascular space volume fraction), and K^trans (a CR extravasation rate measure) parametric maps are presented. The role of the Patlak Plot in DCE-MRI is also considered.