Greater neurobehavioral deficits occur in adult mice after repeated, as compared to single, mild traumatic brain injury (mTBI)
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- 作者：Jessica N. Nicholsa ; jnic@uab.edu" class="auth_mail" title="E-mail the corresponding author ; Alok S. Deshanea ; adeshane@uab.edu" class="auth_mail" title="E-mail the corresponding author ; Tracy L. Niedzielkoa ; tracyniedzielko@uabmc.edu" class="auth_mail" title="E-mail the corresponding author ; Cory D. Smithb ; cdsmith2@uab.edu" class="auth_mail" title="E-mail the corresponding author ; Candace L. Floyda ; candacefloyd@uabmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Traumatic brain injury ; Mild ; Repetitive ; Behavior ; Learning and memory ; Sleep
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：298
- 期：part_PB
- 页码：111-124
- 全文大小：2270 K
文摘
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Mouse model of mTBI exhibited clinically relevant behavioral alterations.
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Repeated mTBIs resulted in learning impairments.
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Performance on species-typical behaviors worsened after repeated mTBIs.
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Increased sleep was experienced after single and repeated mTBI.
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Anxiety and depression were not observed after single or repeated mTBI.