A novel guluronate oligomer improves intestinal transit and survival in cystic fibrosis mice

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• 作者：Megan Vitko^a ; Dana M. Valerio^b ; Philip D. Rye^c ; Edvar Onsø ; yen^c ; Astrid H. Myrset^c ; Arne Dessen^c ; Mitchell L. Drumm^a ; ^b ; Craig A. Hodges^a ; ^b
• 关键词：Cystic fibrosis ; Intestinal transit ; Mucus ; Genetically modified mouse
• 刊名：Journal of Cystic Fibrosis
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：15
• 期：6
• 页码：745-751
• 全文大小：538 K
• 卷排序：15

文摘

Cystic fibrosis (CF) patients experience intestinal complications characterized by the accumulation of thick viscous mucus. CF mice were utilized to determine if a novel guluronate oligomer, OligoG, may be a potential therapy in reducing intestinal mucus and subsequent CF-related intestinal manifestations.MethodsIntestinal transit, intestinal histology, survival and growth were examined in wildtype and CF mice on regular water and OligoG.ConclusionsOligoG improves intestinal transit and survival in CF mice by reducing the accumulation of intestinal mucus. OligoG's ability to directly bind mucin, disrupt mucin interaction and/or sequester calcium allowing for mucin expansion may explain the decrease in mucus accumulation.