Mercury exposure and oxidative stress in communities of the Brazilian Amazon

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• 作者：Denise Grotto ; Juliana Valentini ; Myriam Fillion ; Carlos José ; Souza Passos ; Solange Cristina Garcia ; Donna Mergler ; Fern ; o Barbosa Jr.
• 关键词：Mercury exposure ; Fish consumption ; Oxidative stress ; Antioxidant biomarkers ; Amazon
• 刊名：Science of the Total Environment
• 出版年：2010
• 出版时间：15 January 2010
• 年：2010
• 卷：408
• 期：4
• 页码：806-811
• 全文大小：312 K

文摘

This study was designed to assess possible associations between biomarkers of mercury (Hg) exposure and oxidative stress in fish-eating Amazonian communities. Clinical samples were obtained from riparians living in the Brazilian Amazon. Biomarkers of oxidative stress (glutathione – GSH, glutathione peroxidase - GSH-Px, catalase - CAT, activity and reactivation index of δ-aminolevulinate dehydratase - ALA-D (R % ) were determined in blood. Total Hg was measured in whole blood (B-Hg), plasma (P-Hg) and hair (H-Hg). Association between biomarkers of Hg exposure and oxidative stress were examined using multiple regression models, including age, gender, alcohol consumption, smoking status, fish consumption and then stratified for gender. Significant inverse relations were observed between GSH-Px, GSH, CAT, ALA-D activity and B-Hg or H-Hg (p < 0.05). ALA-D reactivation index was positively related to B-Hg (p < 0.0001). P-Hg was directly related to ALA-D reactivation index and inversely associated with GSH-Px, GSH, and ALA-D activity (p < 0.05). When stratified for gender, women showed significant inverse associations between all biomarkers of Hg exposure and CAT (p < 0.05) or GSH (p < 0.05), while for men only P-Hg showed a significant inverse relation with GSH (p < 0.001). Our results clearly demonstrated an association between Hg exposure and oxidative stress. Moreover, for B-Hg, P-Hg and H-Hg gender differences were present.