Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice
详细信息 查看全文
- 作者：Seizo Okauchi ; okauchi@med.kawasaki-m.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masashi Shimoda ; Atsushi Obata ; Tomohiko Kimura ; Hidenori Hirukawa ; Kenji Kohara ; Tomoatsu Mune ; Kohei Kaku ; Hideaki Kaneto
- 关键词：Pancreatic β-cells ; SGLT2 inhibitor ; β-cell mass and function
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：12 February 2016
- 年：2016
- 卷：470
- 期：3
- 页码：772-782
- 全文大小：2257 K
文摘
- •
SGLT2 inhibitor luseogliflozin ameliorates glycemic control in db/db mice.
- •
Luseogliflozin increases β-cell proliferation and decreases β-cell apoptosis.
- •
Luseogliflozin preserves various β-cell-specific gene expression.
- •
Luseogliflozin decreases various fibrosis-related factors in db/db mice.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |