Effect of central hypothyroidism on Doppler-derived myocardial performance index

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• 作者：Fabio Luiz Casanova Doin ; MD^a ; ^{fabiodoin@terra.com.br} ; Mariana da Rosa Borges ; MD^a ; Orlando Campos ; MD^a ; Antonio Carlos de Camargo Carvalho ; MD^a ; Angelo Amato Vincenzo De Paola ; MD^a ; Marcelo Goulart Paiva ; MD^a ; Julio Abucham ; MD^a ; Valdir Ambrosio Moises ; MD^a
• 刊名：Journal of the American Society of Echocardiography
• 出版年：2004
• 出版时间：June 2004
• 年：2004
• 卷：17
• 期：6
• 页码：622-629
• 全文大小：330 K

文摘

Background

Myocardial performance index (MPI) has been used to assess global ventricular function in different types of cardiac disease. Thyroid hormones influence cardiac performance directly and indirectly by changes in peripheral circulation. The aim of this study was to evaluate the possible effect of central hypothyroidism (CH) on MPI.

Methods

The study included 28 control subjects and 7 patients with CH without cardiac disease. MPI was defined as the sum of isovolumetric contraction time (ICT) and isovolumetric relaxation time divided by ejection time. Patients were submitted to hormonal therapy with thyroxin and the study was repeated after 35 to 42 days.

Results

MPI was significantly higher in patients with CH (0.54 ¡À 0.08) than in control subjects (0.40 ¡À 0.05) (P = .002). The increase in MPI was caused by the prolongation of ICT without a significant variation of isovolumetric relaxation time and ejection time. After hormonal therapy there was a significant reduction of MPI (0.54 ¡À 0.08 vs 0.42 ¡À 0.07; P = .028) and ICT.

Conclusion

MPI was increased in patients with untreated CH. The increase was related to prolongation of ICT and reverted by hormonal therapy.