- 作者：Victor Aboyans ; Philippe Lacroix
- 关键词：Executive compensation ; Bonus plans ; Derivatives
- 刊名：The Lancet
- 出版年：2008
- 出版时间：10 May 2008-16 May 2008
- 年：2008
- 卷：371
- 期：9624
- 页码：1554-1556
- 全文大小：106 K
Findings
Of the 22 articles included, 20 (91 % ) used prospective cohorts. Our analysis included 17 295 patients with 62 413·5 patient-years of follow-up, with a median sample size of 273 patients (range 38–4736) followed up for 4 years (2–7). The rate of myocardial infarction in patients with carotid bruits was 3·69 (95 % CI 2·97–5·40) per 100 patient-years (eight studies) compared with 1·86 (0·24–3·48) per 100 patient-years in those without bruits (two studies). Yearly rates of cardiovascular death were also higher in patients with bruits (16 studies) than in those without (four studies) (2·85 [2·16–3·54] per 100 patient-years vs 1·11 [0·45–1·76] per 100 patient-years). In the four trials in which direct comparisons of patients with and without bruits were possible, the odds ratio for myocardial infarction was 2·15 (1·67–2·78) and for cardiovascular death 2·27 (1·49–3·49).
Interpretation
Auscultation for carotid bruits in patients at risk for heart disease could help select those who might benefit the most from an aggressive modification strategy for cardiovascular risk.
Funding
None.