TNAP stimulates vascular smooth muscle cell trans-differentiation into chondrocytes through calcium deposition and BMP-2 activation: Possible implication in atherosclerotic plaque stability

详细信息    查看全文

• 作者：Maya Fakhry^a ; ^b ; ¹ ; Monika Roszkowska^a ; ^c ; ¹ ; Anne Briolay^a ; Carole Bougault^a ; Alain Guignandon^d ; Juan Ignacio Diaz-Hernandez^e ; Miguel Diaz-Hernandez^e ; Slawomir Pikula^c ; René ; Buchet^a ; Eva Hamade^b ; Bassam Badran^b ; Laurence Bessueille^a ; David Magne^a ; ^{david.magne@univ-lyon1.fr}
• 关键词：Tissue-nonspecific alkaline phosphatase ; Microcalcification ; Inorganic pyrophosphate ; Vascular calcification ; VSMCs ; Chondrocytes
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1863
• 期：3
• 页码：643-653
• 全文大小：829 K
• 卷排序：1863

文摘

TNAP activation in VSMCs appears sufficient to induce calcification. TNAP activation in VSMCs stimulates expression of chondrocyte markers. TNAP inhibition in chondrocytes leads to a loss of multiple differentiation markers. Crystals stimulate expression of BMP-2 in VSMCs. TNAP may stimulate chondrogenesis in VSMCs through crystals and BMP-2.