Septic patients with mitochondrial DNA haplogroup JT have higher respiratory complex IV activity and survival rate

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• 作者：Leonardo Lorente ; MD ; PhDup>aup>up> ; up>up>1up>up> ; up>up>lorentemartin@msn.com" class="auth_mail" title="E-mail the corresponding authorup> ; Mar&iacute ; a M. Mart&iacute ; n ; MD ; PhDup>bup>up> ; up>up>mar.martinvelasco@gmail.com" class="auth_mail" title="E-mail the corresponding authorup> ; Ester L&oacute ; pez-Gallardo ; PhDup>cup>up> ; up>up>esterlop@unizar.es" class="auth_mail" title="E-mail the corresponding authorup> ; Jos&eacute ; Ferreres ; MDup>dup>up> ; up>up>blanquer_jos@gva.es" class="auth_mail" title="E-mail the corresponding authorup> ; Jordi Sol&eacute ; -Viol&aacute ; n ; MD ; PhDup>eup>up> ; up>up>jsolvio@gobiernodecanarias.org" class="auth_mail" title="E-mail the corresponding authorup> ; Lorenzo Labarta ; MDup>fup>up> ; up>up>llabarta@salud.aragon.es" class="auth_mail" title="E-mail the corresponding authorup> ; C&eacute ; sar D&iacute ; az ; MDup>gup>up> ; up>up>incaicos@yahoo.es" class="auth_mail" title="E-mail the corresponding authorup> ; Alejandro Jim&eacute ; nez ; PhDup>hup>up> ; up>up>ajimenezsosa@gmail.com" class="auth_mail" title="E-mail the corresponding authorup> ; Julio Montoya ; PhDup>iup>up> ; up>up>jmontoya@unizar.es" class="auth_mail" title="E-mail the corresponding authorup> ; Eduardo Ruiz-Pesini ; PhDup>jup>up> ; up>up>1up>up> ; up>up>eduruiz@unizar.es" class="auth_mail" title="E-mail the corresponding authorup>
• 关键词：Mitochondrial DNA ; Haplogroup ; OXPHOS ; Cytochrome c oxidase ; Sepsis ; Mortality
• 刊名：Journal of Critical Care
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：33
• 期：Complete
• 页码：95-99
• 全文大小：389 K

文摘

The influence of mitochondrial deoxyribonucleic acid (mtDNA) haplogroup or oxidative phosphorylation system (OXPHOS) function on survival of septic patients has been scarcely studied. However, the association between mtDNA haplogroup, OXPHOS capacity at diagnosis of severe sepsis, and survival has been not previously reported, and that was the objective of the present study.

Methods

This was a prospective, multicenter, observational study. Blood samples from 198 patients at diagnosis of severe sepsis were analyzed to determine mtDNA haplogroup and platelet respiratory complex IV (CIV) specific activity. The end point of the study was 30-day survival.

Results

Septic patients with mtDNA haplogroup JT showed higher 30-day survival than those with mtDNA haplogroup non-JT (31/38 [81.6%] vs 99/160 [61.9%]; P= .02). Septic patients with mtDNA haplogroup JT showed higher platelet CIV specific activity than those with mtDNA haplogroup non-JT (P= .002).

Conclusions

The main novel finding of our study, including the largest series providing data on platelet CIV specific activity according to mtDNA haplogroup in severe septic patients, was that those with mtDNA haplogroup JT showed higher survival and higher platelet CIV specific activity at diagnosis of severe sepsis than patients with mtDNA haplogroup non-JT.