- 作者：Ayako Suzuki?/sup> ; ayako.suzuki@duke.edu ; Manal F. Abdelmalek?/sup> ; Jeffrey B. Schwimmer&Dagger ; ; § ; ; Joel E. Lavine?/sup> ; Ann O. Scheimann¶ ; ; Aynur Unalp– ; Arida# ; Katherine P. Yates# ; Arun J. Sanyal ; Cynthia D. Guy&Dagger ; &Dagger ; ; Anna Mae Diehl?/sup> ; Nonalcoholic Steatohepatitis Clinical Research Network
- 关键词：Sexual Development ; Nonalcoholic Steatohepatitis ; Obesity ; Sex Hormones ; QUICKI
- 刊名：Clinical Gastroenterology and Hepatology
- 出版年：2012
- 出版时间：July, 2012
- 年：2012
- 卷：10
- 期：7
- 页码：786-794
- 全文大小：654 K
Background & Aims
Physiological changes that occur during puberty might affect pathologic features of nonalcoholic fatty liver disease (NAFLD). We investigated associations between pubertal development and clinical and histopathologic features of NAFLD.Methods
We studied 186 children (age <18 years, 143 boys) with biopsy-proven NAFLD. The population was divided into 3 groups on the basis of Tanner stage (prepuberty, puberty, and postpuberty). Clinical characteristics and histologic features were compared among groups. Multivariable regression models were used to adjust for potential confounders.
Results
After adjusting for other factors, hyperuricemia and low levels of high-density-lipoprotein cholesterol were more prevalent among children who entered puberty with lower levels of quantitative insulin sensitivity check index (P < .05). The degree of steatosis, numbers of Mallory-Denk bodies, and diagnostic categories of NAFLD differed among groups (P < .05). There were potential sex differences in associations between stages of puberty and lobular inflammation, hepatocyte ballooning, and borderline steatohepatitis of zone 3; these were therefore not included in multivariable analyses of the overall population. After adjustment for different sets of confounders, patients at or beyond puberty were less likely to have high-grade steatosis, severe portal inflammation, borderline steatohepatitis (zone 1), or a high stage of fibrosis than patients who had not entered puberty (P < .05). On the contrary, the prevalence of Mallory-Denk body was greater among postpuberty subjects (P = .06).
Conclusions
Steatosis, portal inflammation, and fibrosis are less severe during or after puberty than before puberty among subjects with NAFLD. Postpubescent individuals have a lower prevalence of borderline steatohepatitis of zone 1 but are more likely to have Mallory-Denk bodies. These findings indicate that puberty affects the pathologic features of NAFLD.