The serum levels of Receptor Activator of Nuclear Factor-κB Ligand, bone-specific alkaline phosphatase, osteocalcin and osteoprotegerin do not correlate with the radiographically assessed severity of idiopathic hip and knee osteoarthritis

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• 作者：Eustathios Ι ; . Kenanidisp> ; p>p>ap>p> ; p>p>kena76@otenet.grp> ; Michael E. Potoupnisp>1p>p> ; p>p>ap> ; Kyriakos A. Papavasilioup>2p>p> ; p>p>ap> ; Stauros Pelliosp>3p>p> ; p>p>ap> ; Fares E. Sayeghp>3p>p> ; p>p>ap> ; George E. Petsatodisp>4p>p> ; p>p>ap> ; Nikolaos Karatzasp>3p>p> ; p>p>ap> ; George A. Kapetanosp>5p>p> ; p>p>ap>
• 关键词：Bone turnover markers ; Receptor Activator of Nuclear Factor-κ ; B Ligand ; Bone-specific alkaline phosphatase ; Osteocalcin ; Osteoprotegerin ; Hip osteoarthritis ; Knee osteoarthritis
• 刊名：Clinical Biochemistry
• 出版年：2011
• 出版时间：February 2011
• 年：2011
• 卷：44
• 期：2-3
• 页码：203-207
• 全文大小：323 K

文摘

Objectives

Determination of the serum levels of Receptor Activator of Nuclear Factor-Κb Ligand, bone-specific alkaline phosphatase, osteocalcin and osteoprotegerin in patients suffering from osteoarthritis of varying severity and healthy controls and correlation of these results with the patients' age and the radiographically assessed severity of the disease.

Design and methods

<p>Patients suffering from hip (n = 58) or knee (n = 117) osteoarthritis and matched controls (n = 19) were enrolled in this study. Patients underwent physical examination and standard radiographic evaluation before blood sampling.

Results

<p>The serum levels of osteoprotegerin were positively correlated with age in all groups, whereas those of osteocalcin in the ‘knee’ group only. Osteoarthritis' severity and location did not have a statistically significant impact on the mean serum level of any marker in both groups.

Conclusions

<p>Based on our results, none of the studied markers can serve as a surrogate for radiographic imaging in patients suffering from hip and knee osteoarthritis.