Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses
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- 作者：M. Gordon Joyce1 ; 8 ; Adam K. Wheatley1 ; 8 ; Paul V. Thomas1 ; 8 ; Gwo-Yu Chuang1 ; 8 ; Cinque Soto1 ; 8 ; Robert T. Bailer1 ; Aliaksandr Druz1 ; Ivelin S. Georgiev1 ; 2 ; 3 ; Rebecca A. Gillespie1 ; Masaru Kanekiyo1 ; Wing-Pui Kong1 ; Kwanyee Leung1 ; Sandeep N. Narpala1 ; Madhu S. Prabhakaran1 ; Eun Sung Yang1 ; Baoshan Zhang1 ; Yi Zhang1 ; Mangaiarkarasi Asokan1 ; Jeffrey C. Boyington1 ; Tatsiana Bylund1 ; Sam Darko1 ; Christopher R. Lees1 ; Amy Ransier1 ; Chen-Hsiang Shen1 ; Lingshu Wang1 ; James R. Whittle1 ; Xueling Wu1 ; Hadi M. Yassine1 ; Celia Santos1 ; 4 ; Yumiko Matsuoka4 ; Yaroslav Tsybovsky5 ; Ulrich Baxa5 ; NISC Comparative Sequencing Program6
- 刊名：Cell
- 出版年：2016
- 出版时间：28 July 2016
- 年：2016
- 卷：166
- 期：3
- 页码：609-623
- 全文大小：5033 K
文摘
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Isolation of group 1 and group 2 influenza A-neutralizing antibodies from H5N1 vaccinees
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Discovery of three classes of broadly neutralizing antibodies directed to the HA stem
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Delineation of sequence signatures specific for broadly neutralizing antibodies
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Antibody quantification by NGS to guide the development of a universal vaccine