Structural basis for recognition of the type VI spike protein VgrG3 by a cognate immunity protein
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- 作者：Jiulong Zhanga ; b ; 1 ; Heng Zhangd ; 1 ; Zengqiang Gaoa ; Haidai Hue ; Cheng Donga ; c ; dongcheng@ihep.ac.cn" class="auth_mail ; Yu-Hui Donga ; dongyh@ihep.ac.cn" class="auth_mail
- 关键词：T6SS ; the type VI secretion system ; VgrG ; valine&ndash ; glycine repeat protein G ; TsaB ; the type VI secretion antitoxin B protein ; AUC ; analytical ultracentrifugation ; SPR ; surface plasmon resonance ; SAXS ; small-angle X-ray scattering
- 刊名：FEBS Letters
- 出版年：21 May 2014
- 年：2014
- 卷：588
- 期：10
- 页码：1891-1898
- 全文大小：2113 K
文摘
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VgrG3C has inverting glycosyl hydrolase features adopting T4-lysozyme-like fold.
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Oligomeric TsaB may play an important role in biological functions.
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VgrG3C-TsaB complex exits as a heterotetramer in solution.
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TsaB inhibits VgrG3C through the molecular mimicry of its substrate.