ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5
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- 作者：Hui-Lung Sun1 ; 2 ; Ri Cui1 ; JianKang Zhou3 ; Kun-yu Teng4 ; Yung-Hsuan Hsiao5 ; Kotaro Nakanishi6 ; Matteo Fassan1 ; 7 ; Zhenghua Luo1 ; Guqin Shi8 ; Esmerina Tili1 ; 9 ; Huban Kutay4 ; Francesca Lovat1 ; Caterina Vicentini7 ; Han-Li Huang10 ; Shih-Wei Wang11 ; Taewan Kim12 ; Nicola Zanesi1 ; Young-Jun Jeon1 ; Tae Jin Lee1 ; Jih-Hwa Guh13 ; Mien-Chie Hung12 ; 14 ; 15 ; Kalpana Ghoshal4 ; Che-Ming Teng2 ; Yong Peng3 ; yongpeng@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Carlo M. Croce1 ; 16 ; carlo.croce@osumc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ERK ; Exportin-5 ; Pin1 ; nuclear export ; miRNA ; global downregulation ; liver cancer ; miR-122 ; drug resistance ; microtubule
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：14 November 2016
- 年：2016
- 卷：30
- 期：5
- 页码：723-736
- 全文大小：5077 K
文摘
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ERK phosphorylation followed by Pin1-mediated isomerization impairs XPO5 activity
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Downregulation of miR-122 leads to taxol resistance through septin-9 and MARK4
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XPO5 phosphorylation correlates with poor prognosis in HCC patients
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Pin1 and MARK4 are potential targets for clinical intervention in liver cancer