Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation

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• 作者：Ji-chun Zhang^a ; Wei Yao^a ; Chao Dong^a ; Chun Yang^a ; Qian Ren^a ; Min Ma^a ; Mei Han^a ; Jin Wu^a ; Yusuke Ushida^b ; Hiroyuki Suganuma^b ; Kenji Hashimoto^a ; ^{hashimoto@faculty.chiba-u.jp}
• 关键词：Brain-derived neurotrophic factor ; Depression ; Inflammation ; Nrf2 ; Prevention ; Sulforaphane ; Synaptogenesis
• 刊名：The Journal of Nutritional Biochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：39
• 期：Complete
• 页码：134-144
• 全文大小：2142 K
• 卷排序：39

文摘

Inflammation plays a role in the pathophysiology of depression. Sulforaphane (SFN), an isothiocyanate compound derived from broccoli, is a potent activator of the NF-E2-related factor-2 (Nrf2), which plays a role in inflammation. In this study, we examined whether the prevention effects of SFN in lipopolysaccharide (LPS) induced depression-like behavior in mice. Pretreatment with SFN significantly blocked an increase in the serum tumor necrosis factor-α (TNF-α) level and an increase in microglial activation of brain regions after a single administration of LPS (0.5 mg/kg). Furthermore, SFN significantly potentiated increased serum levels of IL-10 after LPS administration. In the tail-suspension test and forced swimming test, SFN significantly attenuated an increase of the immobility time after LPS administration. In addition, SFN significantly recovered to control levels for LPS-induced alterations in the proteins such as brain-derived neurotrophic factor, postsynaptic density protein 95 and AMPA receptor 1 (GluA1) and dendritic spine density in the brain regions. Finally, dietary intake of 0.1% glucoraphanin (a glucosinolate precursor of SFN) food during the juvenile and adolescence could prevent the onset of LPS-induced depression-like behaviors and dendritic spine changes in the brain regions at adulthood. In conclusion, these findings suggest that dietary intake of SFN-rich broccoli sprout has prophylactic effects on inflammation-related depressive symptoms. Therefore, supplementation of SFN-rich broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.