- 作者：Feng Liu ; Maorong Hu ; Shanshan Wang ; Wenbin Guo ; Jingping Zhao ; Jun Li ; Guanglei Xun ; Zhiliang Long ; Jianwei Zhang ; Yifeng Wang ; Ling Zeng ; Qing Gao ; Sarah C. Wooderson ; Jindong Chen ; Huafu Chen
- 关键词：LLD ; late-life depression ; fMRI ; functional magnetic resonance imaging ; Cohe-ReHo ; coherence-based regional homogeneity ; PET ; positron emission tomography ; PCU ; precuneus ; ACC ; anterior cingulate cortex ; DLPFC ; dorsolateral prefrontal cortex ; CAU ; caudate
- 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
- 出版年：2012
- 出版时间：3 December, 2012
- 年：2012
- 卷：39
- 期：2
- 页码：326-331
- 全文大小：575 K
Background
The previous resting perfusion or task-based studies have provided evidence of functional changes in the brains of patients with late-life depression (LLD). Little is known, so far, about the changes in the spontaneous brain activity in LLD during the resting state. The aim of this study was to investigate the spontaneous neural activity in first-episode, treatment-naive patients with LLD by using resting-state functional magnetic resonance imaging (fMRI).Methods
A novel analytical method, coherence-based regional homogeneity (Cohe-ReHo), was used to assess regional spontaneous neural activity during the resting state in 15 first-episode, treatment-naive patients with LLD and 15 age- and gender-matched healthy controls.
Results
Compared to the healthy controls, the LLD group showed significantly decreased Cohe-ReHo in left caudate nucleus, right anterior cingulate gyrus, left dorsolateral prefrontal cortex, right angular gyrus, bilateral medial prefrontal cortex, and right precuneus, while significantly increased Cohe-ReHo in left cerebellum posterior lobe, left superior temporal gyrus, bilateral supplementary motor area, and right postcentral gyrus (p < 0.005, corrected for multiple comparisons).
Conclusions
These findings indicated abnormal spontaneous neural activity was distributed extensively in first-episode, treatment-naive patients with LLD during the resting state. Our results might supply a novel way to look into the underlying pathophysiology mechanisms of patients with LLD.