The Central Adriatic Basin (CAB) and the Southern Adriatic Basin (SAB) are foreland (or foredeep) basins relative to the non-coeval Apenninic and Dinaric-Hellenic orogenic systems and currently characterized by different physiographies; these are separated by a major forebulge of the Adriatic lithosphere running throughout the Adriatic region from Istria to the Gargano promontory. The clastic basin filling of the CAB is mostly Plio-Pleistocene whereas it is Upper Oligocene-Pleistocene in the SAB. It is proposed that the Messinian salinity crisis and relative eustatic lowstand affected the subsequent tectono-sedimentary evolution of the CAB in terms of subsidence rate and depositional style.