Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax

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• 作者：Luciane Moreno Storti-Melo^a ; ^b ; ^{stortilu@yahoo.com.br} ; Daniela Reis da Costa^b ; Wanessa Christina Souza-Neiras^b ; ^c ; Gustavo Capatti Cassiano^b ; ^d ; Vanja Suely Calvosa D&rsquo ; Almeida Couto^e ; Marinete Marins Pó ; voa^f ; Irene da Silva Soares^g ; Luzia Helena de Carvalho^h ; Myrian Arevalo-Herreraⁱ ; Só ; crates Herreraⁱ ; Andrea Regina Baptista Rossit^j ; José ; Antonio Cordeiro^k ; Luiz Carlos de Mattos^l ; Ricardo Luiz Dantas Machado^b
• 关键词：Plasmodium vivax ; HLA-DRB1 ; Antibody response
• 刊名：Acta Tropica
• 出版年：2012
• 出版时间：February 2012
• 年：2012
• 卷：121
• 期：2
• 页码：152-155
• 全文大小：207 K

文摘

We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HLA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the HLA-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria.