Selacyclicbiflavone A, an unusual macrocyclic biflavone from Selaginella uncinata (Desv.) Spring

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• 作者：Hui Zou^a ; ^c ; Ping-Sheng Xu^a ; Rui Liu^b ; Zhen-Xing Zou^b ; Jing Li^b ; Ai-Guo Zhong^d ; Jian-Zhong Hu^a ; Kang-Ping Xu^b ; ^{xukp376@aliyun.com" class="auth_mail" title="E-mail the corresponding author} ; Gui-Shan Tan^a ; ^b ; ^{tgs395@csu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Selaginella uncinata ; Selacyclicbiflavone A ; Selaginella ; Biflavone ; Biosynthetic pathway
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：24 February 2016
• 年：2016
• 卷：57
• 期：8
• 页码：892-894
• 全文大小：637 K

文摘

An unusual macrocyclic biflavone, selacyclicbiflavone A (1), have been isolated from Selaginella uncinata. The structure was elucidated on the basis of rigorous spectroscopic analysis including 1D and 2D NMR experiments as well as HRESIMS techniques. The absolute stereochemistry of compound 1 was further confirmed by comparing experimental data with calculated electronic circular dichroism (ECD) spectra. This is the first report of the macrocyclic biflavone with an unprecedented methylene bridge. A possible biosynthetic pathway was also postulated.