GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis

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• 作者：Edward J. Sanderlin^a ; ¹ ; Nancy R. Leffler^a ; ¹ ; Kvin Lertpiriyapong^b ; ¹ ; Qi Cai^c ; Heng Hong^c ; Vasudevan Bakthavatchalu^d ; James G. Fox^d ; Joani Zary Oswald^e ; Calvin R. Justus^a ; Elizabeth A. Krewson^e ; Dorcas O&rsquo ; Rourke^b ; Li V. Yang^a ; ^e ; ^{yangl@ecu.edu}
• 关键词：GPR4 ; Inflammatory bowel disease (IBD) ; Acidosis ; Endothelial cell ; Inflammation
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1863
• 期：2
• 页码：569-584
• 全文大小：5703 K
• 卷排序：1863

文摘

GPR4 deficiency reduces acute intestinal inflammation in a mouse colitis model. GPR4 gene expression is upregulated in inflamed mouse and human intestinal tissues. Vascular endothelial cells are the major cell type in which GPR4 is expressed. GPR4 deficiency decreases endothelial adhesion molecule expression in inflamed mouse intestines.