FoxP1 marks medium spiny neurons from precursors to maturity and is required for their differentiation
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- 作者：S.V. Preciousa ; 1 ; C.M. Kellya ; 1 ; 2 ; A.E. Reddingtona ; N.N. Vinha ; R.C. Sticklanda ; V. Pekarika ; e ; C. Scherfd ; R. Jeyasinghama ; J. Glasbeya ; M. Holeitera ; L. Jonesc ; M.V. Taylorb ; 3 ; A.E. Rossera ; c ; 3 ; rosserae@cf.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：DARPP-32 ; dopamine and cyclic adenosine 3&prime ; 5&prime ; - monophosphate-regulated phosphoprotein ; 32 ; kDa ; FoxP1 ; Forkhead box protein P1 ; HD ; Huntington's disease ; MSN ; medium spiny projection neuron
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：282
- 期：Complete
- 页码：9-18
- 全文大小：2279 K
文摘
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FoxP1 was the most highly up-regulated gene during MSN-neurogenesis.
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FoxP1 expression persists in the striatum through development to adulthood.
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FoxP1 is retained in WGE cells in culture and after neural transplantation.
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Striatal DARPP-32 expression is lost in a mouse FoxP1 knock-out.