IL10 polymorphisms associated with Beh莽et鈥檚 disease in Chinese Han

详细信息    查看全文

• 作者：Ziyan Wu ; Wenjie Zheng ; Juanjuan Xu ; Fei Sun ; Hua Chen ; Ping Li ; Si Chen ; Ming Shen ; Wen Zhang ; Xin You ; Qingjun Wu ; Fengchun Zhang ; Yongzhe Li
• 关键词：BD ; Behç ; et&rsquo ; s disease ; SLE ; systemic lupus rythematosus ; RA ; rheumatoid arthritis ; UC ; ulcerative colitis ; GWAS ; genome-wide association studies ; SNP ; single nucleotide polymorphism ; LD ; linkage disequilibrium
• 刊名：Human Immunology
• 出版年：March, 2014
• 年：2014
• 卷：75
• 期：3
• 页码：271-276
• 全文大小：746 K

文摘

Objective

IL-10 is a potent anti-inflammatory cytokine that plays important roles in the pathogenesis of Beh莽et鈥檚 disease (BD). Two genome-wide association studies have identified IL10 as a potential risk factor for BD. Here, we investigated the association between IL10 polymorphisms and BD in Chinese Han.

Methods

407 BD patients and 679 healthy controls were enrolled, and genotyped by Sequenom MassArray system (Sequenom iPLEX assay, San Diego, CA).

Results

The frequency of risk allele of rs1800871 was notably higher in BD patients than in controls (71.9% vs. 66.2%, OR: 1.30, 95%CI: 1.08-1.58, p_c = 0.024). Similarly, rs1518111, which showed strong linkage disequilibrium (r² = 1) with allele rs1800871, was also associated with BD (p_c = 0.026). Rs3021094 was in association with BD in a dominant model (p_c = 0.035), and the haplotype (GACC) formed by rs1518111, rs3021094, rs3790622, and rs1800871 was associated with BD (p_c = 0.023). Results obtained from meta-analysis combined with our data showed that rs1800871 and rs1518111 were associated with BD.

Conclusion

IL10 may be the susceptibility gene for BD in Chinese Han population.