Effective inhibition of the early copper ion burst release by purine adsorption in simulated uterine fluids

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• 作者：Concepció ; n Alonso^a ; ^{concepcion.alonso@uam.es" class="auth_mail" title="E-mail the corresponding author} ; Elena Casero^b ; ^{elena.casero@uam.es" class="auth_mail" title="E-mail the corresponding author} ; Elisa Romá ; n^c ; ^{eroman@icmm.csic.es" class="auth_mail" title="E-mail the corresponding author} ; Sara F.-P. Campos^a ; Mó ; nica Ferná ; ndez Lorenzo de Mele^d ; ^e ; ^{mmele@inifta.unlp.edu.ar" class="auth_mail" title="E-mail the corresponding author}
• 关键词：purine ; adsorption ; corrosion inhibition ; copper ions release ; urea
• 刊名：Electrochimica Acta
• 出版年：2016
• 出版时间：20 January 2016
• 年：2016
• 卷：189
• 期：Complete
• 页码：54-63
• 全文大小：1307 K

文摘

Burst release of ions from copper-based intrauterine devices (IUD) occurs during the first day after the insertion in uterus and may induce side effects in the users. In the present work, we investigate the mechanism of the inhibitory action of ex-situ pretreatment of copper samples with purine (10⁻²-10⁻⁴ M PU) in simulated uterine fluids (SUF) with and without urea (UR). Quartz crystal microbalance measurements showed that the PU inhibition effect depends on the concentration and adsorption time increasing in presence of chloride. In particular, PU pretreatment (10⁻² M-10⁻³ M) leads to an inhibition of copper ions release over 24 h immersion time in SUF, without and with UR. UR may act for a few hours as a weak corrosion inhibitor leading to temporary control of corrosion, but the protection decreases quickly due to formation of soluble Cu-UR complexes, being the total amount of released copper higher when UR is present.